Reactions of carboxylic acids and carboxylic acid derivatives figure prominently on the new MCAT because they figure prominently in biochemistry. From the mechanism of a serine protease to triglyceride synthesis, acyl substitution is omnipresent in biochemistry. Acyl substitution is reaction pathway for transforming one carboxylic acid derivative into another, moving between carboxylic acids, amides, esters, anhydrides, thioesters and acyl phosphates. Other carboxylic acid reactions important in biochemistry include Claisen condensation, alpha addition, and formation and use of a carboxylate nucleophile. Additionally, the way that thiamine pyrophosphate (TPP) assists decarboxylation of an α-keto acid in pyruvate dehydrogenase and α-ketoglutarate dehydrogenase is very similar to the benchtop decarboxylation of a β-keto acid.
nucleophilic acyl substitution mechanism





Nucleophilic acyl substitution mechanism.













The WikiPremed MCAT Course is a comprehensive course in the undergraduate level general sciences. Undergraduate level physics, chemistry, organic chemistry and biology are presented by this course as a unified whole within a spiraling curriculum. Please read our policies on Privacy and Shipping & Returns.  Contact Us. MCAT is a registered trademark of the Association of American Medical Colleges, which does not endorse the WikiPremed Course. WikiPremed offers the customers of our publications or our teaching services no guarantees regarding eventual performance on the MCAT.


Creative Commons License
WikiPremed is a trademark of Wisebridge Learning Systems LLC. The work of WikiPremed is published under a Creative Commons Attribution NonCommercial ShareAlike License. There are elements of work here, such as a subset of the images in the archive from WikiPedia, that originated as GNU General Public License works, so take care to follow the unique stipulations of that license in printed reproductions.