Consisting of about 95% polysaccharide (glycosaminoglycans), 5% protein, proteoglycans serve as the ground substance (extracellular medium) of many types of connective tissue. What is the difference between a glycoprotein and a proteoglycan? Proteoglycans represent a special class of glycoproteins where, because they are so heavily glycosylated, the balance has shifted toward carbohydrate in the nomenclature. The protein does play an important role as the core of the structure, with covalently attached carbohydrate polymers. The carbohydrate chains are negatively charged at neutral pH due to sulphate and uronic acid groups in proteoglycans.

Proteoglycans are a major component of the extracellular matrix, especially within connective tissue.

The WikiPremed MCAT Course is a comprehensive course in the undergraduate level general sciences. Undergraduate level physics, chemistry, organic chemistry and biology are presented by this course as a unified whole within a spiraling curriculum. Please read our policies on Privacy and Shipping & Returns.  Contact Us. MCAT is a registered trademark of the Association of American Medical Colleges, which does not endorse the WikiPremed Course. WikiPremed offers the customers of our publications or our teaching services no guarantees regarding eventual performance on the MCAT.

Creative Commons License
WikiPremed is a trademark of Wisebridge Learning Systems LLC. The work of WikiPremed is published under a Creative Commons Attribution NonCommercial ShareAlike License. There are elements of work here, such as a subset of the images in the archive from WikiPedia, that originated as GNU General Public License works, so take care to follow the unique stipulations of that license in printed reproductions.