We will use the Interdisciplinary Discussions to provide a bit of commentary on the citric acid cycle as we did with glycolysis. Please bear in mind that biochemistry is not an MCAT prerequesite. However, the expectation on the exam is a bit more advanced in the biochemistry topics than the typical Bio 101 course. Furthermore, biochemistry exerts a pull on the organic chemistry emphasis. Reactions which are very important in biochemistry appear on the MCAT with great frequency. So rest assured that the exam will not be interested in very specific recall regarding biochemical pathways. However, preparing your ability to read and comprehend passages with biochemistry nomenclature is an important task for the MCAT. In summary, although you are not expected to have mastered Biochemistry before the MCAT, a good comfort level with the subject matter is essential for a superior score.

It is a good idea to open your biology textbook to its graphic of the citric acid cycle pathway as you read these discussions. Let us begin our discussion of the citric acid cycle with acetyl CoA, our two carbon remainder from glycolysis. In a series of reactions catalyzed by citrate synthase, acetyl CoA first combines with oxaloacetate, a four carbon form, by means of an aldol condensation (aldol condensation again!). The CoA portion of is then removed by hydrolysis of the thioester linkage in an acyl exchange mechanism.












The WikiPremed MCAT Course is a comprehensive course in the undergraduate level general sciences. Undergraduate level physics, chemistry, organic chemistry and biology are presented by this course as a unified whole within a spiraling curriculum. Please read our policies on Privacy and Shipping & Returns.  Contact Us. MCAT is a registered trademark of the Association of American Medical Colleges, which does not endorse the WikiPremed Course. WikiPremed offers the customers of our publications or our teaching services no guarantees regarding eventual performance on the MCAT.


Creative Commons License
WikiPremed is a trademark of Wisebridge Learning Systems LLC. The work of WikiPremed is published under a Creative Commons Attribution NonCommercial ShareAlike License. There are elements of work here, such as a subset of the images in the archive from WikiPedia, that originated as GNU General Public License works, so take care to follow the unique stipulations of that license in printed reproductions.