Gene shuffling under the control of endonucleases rearranges the gene coding for the light and heavy chains of an antibody. Gene segments for variable sequences are randomly selected from sets of possible segments and spliced to form the final gene to be transcribed and translated. Furthermore, other rearrangements in gene segments lead to antibody class switching; i.e. the same B cell creates first IgM and then IgG antibodies (Plasma cells have much rough ER.). Variations can also occur at the level of RNA processing, i.e. the insertion of a hydrophobic portion making an IgM membrane bound.

The WikiPremed MCAT Course is a comprehensive course in the undergraduate level general sciences. Undergraduate level physics, chemistry, organic chemistry and biology are presented by this course as a unified whole within a spiraling curriculum. Please read our policies on Privacy and Shipping & Returns.  Contact Us. MCAT is a registered trademark of the Association of American Medical Colleges, which does not endorse the WikiPremed Course. WikiPremed offers the customers of our publications or our teaching services no guarantees regarding eventual performance on the MCAT.

Creative Commons License
WikiPremed is a trademark of Wisebridge Learning Systems LLC. The work of WikiPremed is published under a Creative Commons Attribution NonCommercial ShareAlike License. There are elements of work here, such as a subset of the images in the archive from WikiPedia, that originated as GNU General Public License works, so take care to follow the unique stipulations of that license in printed reproductions.